منابع مشابه
Genetic polymorphism of N142D GSTO2 and susceptibility to breast cancer: a meta-analysis
To establish a comprehensive picture of the relationship between glutathione S-transferase omega 2 (GSTO2; MIM: 612314) gene N142D variant (rs. 156697) and breast cancer risk, the present meta-analysis was carried out. Studies published up to July 2012 with information about GSTO2 polymorphism and breast cancer risk were identified using several electronic databases. We identified 4 eligible st...
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Triple-negative breast cancers (TNBC), defined by the absence of estrogen receptor, progesterone receptor, and HER-2 expression, account for 12% to 24% of all breast cancers. TNBC is associated with early recurrence of disease and poor outcome. Germline mutations in the BRCA1 and BRCA2 breast cancer susceptibility genes have been associated with up to 15% of TNBC, and TNBC accounts for 70% of b...
متن کاملRecent advances in understanding of genetic susceptibility to breast cancer.
The breast cancer susceptibility gene, BRCA1, was isolated in 1994. Recent investigations into the genetic epidemiology of BRCA1 have revealed an unexpectedly high prevalence of mutations amongst Ashkenazi Jews. Analyses of BRCA1 function have indicated that it may act as an inhibitor of cell proliferation and is necessary for normal development in the mouse. The presence of a motif in BRCA1 ch...
متن کاملgenetic polymorphism of n142d gsto2 and susceptibility to breast cancer: a meta-analysis
to establish a comprehensive picture of the relationship between glutathione s-transferase omega 2 (gsto2; mim: 612314) gene n142d variant (rs. 156697) and breast cancer risk, the present meta-analysis was carried out. studies published up to july 2012 with information about gsto2 polymorphism and breast cancer risk were identified using several electronic databases. we identified 4 eligible st...
متن کاملGenetic susceptibility to lung cancer.
Lung cancer is a highly environmental disease, but cancer researchers have long been interested in investigating genetic susceptibility to lung cancer. This paper is a historical review and provides updated perspectives on lung cancer susceptibility research. The recent introduction of easier genotyping methods and the availability of an almost complete human genome database facilitated the ass...
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ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2010
ISSN: 1574-7891
DOI: 10.1016/j.molonc.2010.04.011